Fundamentos fisiopatológicos na doença de alzheimer segundos estudos neuro-histológicos : uma revisão de literatura narrativa

Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative and progressive disease, which presents clinical signs of progressive atrophy in several brain areas. This document's main objective is to carry out a general investigation, based on a scientific study of different sources of AD origin, based on pre-established literature and the analysis of relevant articles, referring to aspects associated with histopathology in AD disease. Alzheimer's. This research consists of an analysis of specialized literature of an exploratory nature, resulting in a bibliographical review regarding the neurohistology process of Alzheimer's Disease. The literary review carried out consisted of the analysis of around 20 scientific articles, 6 of which proved to be relevant to the main focus addressed in the text. Within a detailed analysis of 6 academic articles, 4 showed changes in immune cells as the main determinant of deaths from DA and 2 indicated neuronal events as a criterion for establishing clinical signs and symptoms. The results of this research indicate that in Brazil, around 1.2 million people live with some form of disorder and 100,000 new cases are diagnosed per year. It can be concluded that there is no consensus among AD researchers. Therefore, it is essential to establish new studies that facilitate interprofessional understanding of neurohistology in Alzheimer's disease and its pathophysiological mechanisms.