Potential impact of the covid-19 in hiv-infected individuals: a systematic review

Abstract

Background: Much has been studied about the virus SARS-Cov-2, its effects, and possibles treatment effective. Nevertheless, little is known about the interactions of this infection with others infectious diseases. Objective: The aim is to clarify the clinical features and morbidity and mortality outcomes of patients with co-infection COVID-19 and HIV/AIDS. Data sources: MEDLINE, Web of Science, Embase, CINAHL, LILACS, Scopus, clinicaltrials.gov, Cochrane. Study eligibility criteria: all the studies that were describing patients affected by the SARS-CoV-2/COVID-19 and with HIV/AIDS; there were no language restrictions while selecting the studies; published after 2019. Study appraisal: JBI Levels of Evidence - Joanna Briggs Institute. Synthesis methods: Two authors separately screened the search results using the titles and abstracts. The selection of the studies was summarized in a PRISMA flow diagram. Results: Chest CT was observed in patients with pneumonia by SARS - CoV - 2 with findings of multiple ground glass (GGO) opacities in the lungs, there is a need for supplemental oxygenation. One patient developed encephalopathy and complicated tonic-clonic seizures; four patients were transplanted (two liver and two kidneys), one patient developed severe SARS-CoV-2 pneumonia and 30 patients died (mortality rate of 11%). Conclusion: HIV did not show any relevance direct with the occurrence of COVID-19. Some studies suggest that HIV-1 infection through induction levels of IFN-I, may to some extent, cause protection apparent SARS-CoV-2 infection, thus leading to undetectable RNA. Besides that, some authors suggest retroviral routinely used to control HIV infection could be used to prevent infection by COVID-19.