A associação entre médias de linfócitos e PCR e sua relação com o estado nutricional de pacientes de transplante de medula óssea

Abstract

Bone marrow provides the site for hematopoiesis and contains hematopoietic stem cells (CTH), which have the ability to self-reproduce and differentiate. Bone marrow can be affected by diseases that can compromise the normal production of blood cells, as an intervention for these diseases is bone marrow transplantation (BMT), which can be classified as autologous or allogeneic. This is a treatment in which the deficient marrow is replaced with new bone marrow. Before BMT, a conditioning regimen is performed, generating immunosuppression and a series of adverse effects that impact the patient's nutritional status; make necessary biochemical and anthropometric assessments at all stages of treatment. Then, research was developed with the objective of observing the association between total lymphocytes and CRP of patients admitted to a hospital in the city of Natal / RN, evaluating 14 individuals, 5 men, and 9 women; including patients over the age of 18 and candidates for bone marrow transplantation. Weight, BMI classification, and biochemical data such as CRP, albumin, neutrophils, and total lymphocytes were evaluated. Finally, Spearman's correlation test was performed, where it was possible to observe a positive correlation between total lymphocytes-PCR and a negative correlation between total lymphocytes-albumin, indicating that the greater the inflammation in these patients, the greater the immune response, too. as the nutritional risk.