Hiperparatireoidismo secundário à doença renal crônica e a associação com cálcio, fósforo e vitamina D

Abstract

Chronic kidney disease is a pathology that consists of loss of kidney function. Chronic renal patients have a great predisposition for the development of secondary hyperparathyroidism due to the increase in the production of parathyroid hormone that occurs due to the loss of control of the levels of calcium, phosphorus and vitamin D. The objective of this integrative review is the analysis of hyperparathyroidism secondary to the disease chronic kidney disease and its associations with the metabolism of calcium, phosphorus and vitamin D, thus, a survey was carried out with five eligibility criteria to classify the studies that could be added to the research base, followed by an assessment of the methodological quality, attributing points for each eligibility criterion met by the chosen study, finally, a statistical analysis with five steps in order to evaluate and compare the conclusions of the studies. The search resulted in 29 studies from three platforms, after excluding 24 studies that did not fit the proposal of this integrative review, a quality assessment was performed with the 5 remaining studies. This process resulted in two studies with 2 points and three studies with 5 points, so that each point is equivalent to an eligibility criterion. Thus, 5 studies were classified as suitable for use in this integrative review, which indicate that chronic renal patients should be constantly monitored to avoid the development of secondary hyperparathyroidism, and, for those who already suffer from the disease, the use of calcimimetics and Vitamin D receptor activators should be administered to control hyperparathyroidism.